From 1961 to 1963 he and his wife, Betty, co-hosted "The All-Night Show" in Los Angeles on KTIV, Channel 11.
Joe felt that it was a waste that TV stations went off the air from midnight until 6 AM in those days, so he bought that six hour block of time and he and Betty played movies all night on TV.
They also interviewed guests live like (Sammy Davis, Jr., Dinah Shore, Frank Sinatra, and countless others.
Their show was the first all-night show in the US. (Midnight to Eight AM.)
Always thinking, Joe knew there was an audience up all night made up of swing shift workers, hospital workers, city workers, (policemen, firefighters) who would watch TV - if there was something good to watch.
He was right.
Joe sold his own late-night advertising time, but few potential advertisers believed the late-night audience was worthwhile.
So Joe to offset the costs of his television time, Joe turned to mail order promoted his own products during the show. Selling things ranging from glow in dark Christmas ornaments to vitamins, basically whatever he could make a profit on.
He wrote his own advertising copy for both the show and his ads. And as a result of a combination of his like ability, ad copy expertise and the fact that he had a monopoly on TV (no other shows broadcast after 1:00 AM) he quickly became rich from his own all - night TV show.
But nothing lasts forever and in 1962 the station that televised Karbo’s program was sold to the Metromedia Corporation.
The station would not re-negotiate his contract because they’d witnessed the success of Joe’s format and now wanted to do all-night TV themselves.
When Joe and Betty's show was forced off the air, Joe was left with lots of product and no way to sell it.
To make matters worse Karbo had massive debt load from the purchase of inventory for things he sold on the show.